Schizophrenia Research

Large Study Confirms Major Hypotheses in Schizophrenia Research
Although researchers don’t yet have a good picture of what causes schizophrenia, they do know that both genetics and environment play a role. A small minority of people with the illness have missing or extra chunks of DNA known as copy number variants (CNVs). Researchers have turned to these large spans of altered DNA in the search for gene changes that contribute to schizophrenia.
The largest study of CNVs in schizophrenia so far reports the first strong genetic evidence that molecules involved in neuronal communication with GABA, one of the brain’s major neurotransmitters, may play a role in schizophrenia. The new findings, published in the June 3rd issue of Neuron, are consistent with a large amount of non-genetic research from people with schizophrenia as well as animal models that also point to changes in GABA signaling as underlying the cognitive problems of the illness. The research also confirms previous evidence implicating the other major neurotransmitter, glutamate.
Read the entire article at the Brain & Behavior Research Foundation.
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